ATS Xtend™ Offline

Dissolution tester automatically withdraw, filter, and collect samples in tubes, capped LC vials, or well plates

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SAMPLING - Always take samples the same way at reproducible withdrawal positions
OFFLINE - Collect samples in glass tubes, capped LC vials, or HPLC / UPLC wellplates
METHODS - Program multiple timepoints and automatically replace withdrawn sampling volumes
FAST - Timepoint intervals of less than 1 minute possible with powerful piston pump
MODIFIED RELEASE - Automatically change filters at defined timepoints for your DR / MR methods
FINE FILTRATION - Push through filters with a minimum porosity of 0.2 microns for offline HPLC / UPLC analysis
FLEXIBLE - Maintain full flexibility without dedicating your dissolution tester to an analytical device

Automation

Dissolution process steps with a semi-automated Offline dissolution testing system.

Highlights

Reproducible sampling.

The ATS Xtend™ Offline automates essential steps of your dissolution test - making them highly repeatable. Samples are simultaneously taken from 6-8 vessels, filtered, and collected in tubes, capped LC vials, or wellplates. Standardization of the sampling position, pulling force, volume, timing, and filtration reduces potential sources of variability and makes your testing process more efficient.

Multi-purpose media selector.

Perform one-touch sample line cleaning on completion of a test. Simply connect a water tank to the multi-purpose selector of your Xtend™ dissolution bath and start the automated tube-flushing routine. Up to 3 additional sources can be connected to automatically replace withdrawn sampling volumes during dissolution tests with multiple timepoints or to execute pH changes by adding media.

Filters with a minimum porosity of 0.2 microns for the filterstation dissolution tester USP 1256

Highly effective filtration.

Xtend™ dissolution line is built on flexible sampling and filtration. Mimic existing environments when replacing old dissolution testers to ensure comparability of results. Use tip filters or sieves for pre-filtration, disc filters in the suction head, or standard syringe filters. Require fine filtration for your analytical finish? No problem - the powerful CP piston pump can push through filters down to 0.2 microns and also handles foaming media with surfactants.

User-friendly EasyTouch™ interface assists the operator in executing tasks for dissolution tester AT Xtend

Easy to use.

Operators simply select a method on the EasyTouch™ user interface and press START to initiate the dissolution test. In full compliance with the FDA data integrity guidance on segregation of roles, only authorized personnel like supervisors or administrators can modify existing methods or create new recipes. To share methods between multiple systems, the ATS Xtend™ can be conveniently networked with data management software.

Individual video monitoring of each dissolution tester vessel throughout the test.

Monitoring dissolution.

Use AutoLift™ to automatically protocol temperatures inside all 6-8 vessels before test start, when taking samples, or at any point during the test in your dissolution tester. Additionally, you can record dissolution behavior inside each vessel with CenterView™ to document that proper procedure has been followed, or more importantly, that a deviation has occurred.

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